One of the side effects of prolonged steroid usage such as a treatment for acute or chronic graph-versus-host disease is the possible infliction of Avasculor Necrosis (AVN), which is the death of bone (usually joints or long bones) due to the lack of blood supply.

Another side effect can be scar tissue on joints, particularly wrists, hands, fingers, hips, knees. Inflamation around these joins is similar to arthritis.

Treatments vary. One treatment path might include drugs, such as Sirolinus (a Rapamune drug).

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